通过测试webBrowser与IE缓存和Cookie都存放在Local Settings\Temporary Internet Files，我们可以直接调用IE API进行清除
解决方案1：
public enum ShowCommands : int { SW_HIDE = 0, SW_SHOWNORMAL = 1, SW_NORMAL = 1, SW_SHOWMINIMIZED = 2, SW_SHOWMAXIMIZED = 3, SW_MAXIMIZE = 3, SW_SHOWNOACTIVATE = 4, SW_SHOW = 5, SW_MINIMIZE = 6, SW_SHOWMINNOACTIVE = 7, SW_SHOWNA = 8, SW_RESTORE = 9, SW_SHOWDEFAULT = 10, SW_FORCEMINIMIZE = 11, SW_MAX = 11 }
[DllImport("shell32.dll")] static extern IntPtr ShellExecute( IntPtr hwnd, string lpOperation, string lpFile, string lpParameters, string lpDirectory, ShowCommands nShowCmd);
//清除IE临时文件 ShellExecute(IntPtr.Zero, "open", "rundll32.exe", " InetCpl.cpl,ClearMyTracksByProcess 255", "", ShowCommands.SW_HIDE);
其中ClearMyTracksByProcess 可进行选择设置 ：
Temporary Internet Files （Internet临时文件）
RunDll32.exe InetCpl.cpl,ClearMyTracksByProcess 8
Cookies
RunDll32.exe InetCpl.cpl,ClearMyTracksByProcess 2
History (历史记录)
RunDll32.exe InetCpl.cpl,ClearMyTracksByProcess 1
Form. Data （表单数据）
RunDll32.exe InetCpl.cpl,ClearMyTracksByProcess 16
Passwords (密码）
RunDll32.exe InetCpl.cpl,ClearMyTracksByProcess 32
Delete All （全部删除）
RunDll32.exe InetCpl.cpl,ClearMyTracksByProcess 255
解决方案2：快速清除webBrowser Cookie
wb.Document.Cookie.Remove(0, (wb.Document.Cookie.Count - 1))
清除webBrowser 缓存和Cookie的解决方案,布布扣,bubuko.com
原文地址：http://www.cnblogs.com/mvc2014/p/3775964.html
