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吡啶酮

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结构式物理化学性质
常用名 吡咯烷二硫代甲酸铵 英文名 4-HYDROXYPYRIDINE
CAS号 108-96-3 分子量 95.09930
密度 1.111 g/cm3 沸点 230-235 °C12 mm Hg(lit.)
分子式 C5H5NO 熔点 150-151 °C(lit.)
 产品用途 
用于合成利尿药物托拉塞米或其他药物中间体。 

物理化学性质

[ 密度 ]: 1.111 g/cm3
[ 沸点 ]: 230-235 °C12 mm Hg(lit.)
[ 熔点 ]: 150-151 °C(lit.)
[ 分子式 ]: C5H5NO
[ 分子量 ]: 95.09930
[ 闪点 ]: 107.8ºC
[ 精确质量 ]: 95.03710
[ PSA ]: 32.86000
[ LogP ]: 0.37490
[ 外观性状 ]: 米色粉末
[ 蒸汽压 ]: 0.265mmHg at 25°C
[ 折射率 ]: 1.513

MSDS

Name: 4-(1H)-Pyridone (Pract) 97% (UV-VIS) Material Safety Data Sheet
Synonym:  
CAS: 108-96-3
Section 1 - Chemical Product MSDS Name:4-(1H)-Pyridone (Pract) 97% (UV-VIS) Material Safety Data Sheet 
Synonym: 

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
108-96-3 4-(1H)-Pyridone 97 203-633-2
Hazard Symbols: None Listed. 
Risk Phrases: None Listed. 

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW 
The toxicological properties of this material have not been fully investigated. 
Potential Health Effects 
Eye: 
May cause eye irritation. The toxicological properties of this material have not been fully investigated. 
Skin: 
May cause skin irritation. The toxicological properties of this material have not been fully investigated. 
Ingestion: 
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. The toxicological properties of this substance have not been fully investigated. 
Inhalation: 
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated. 
Chronic: 
No information found. 

Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. 
Skin: 
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. 
Ingestion: 
If victim is conscious and alert, give 2-4 cupfuls of milk or water. 
Never give anything by mouth to an unconscious person. Get medical aid immediately. 
Inhalation: 
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. 
Notes to Physician: 

Section 5 - FIRE FIGHTING MEASURES
General Information: 
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. 
Extinguishing Media: 
Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam. 

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8. 
Spills/Leaks: 
Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Provide ventilation. 

Section 7 - HANDLING and STORAGE
Handling: 
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. 
Storage: 
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. 

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls: 
Use adequate ventilation to keep airborne concentrations low. 
Exposure Limits CAS# 108-96-3: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA‘s eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. 
Skin: 
Wear appropriate protective gloves to prevent skin exposure. 
Clothing: 
Wear appropriate protective clothing to prevent skin exposure. 
Respirators: 
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. 

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Powder 
Color: beige 
Odor: Not available. 
pH: Not available. 
Vapor Pressure: Not available. 
Viscosity: Not available. 
Boiling Point: Not available. 
Freezing/Melting Point: 140 deg C 
Autoignition Temperature: Not available. 
Flash Point: Not available. 
Explosion Limits, lower: Not available. 
Explosion Limits, upper: Not available. 
Decomposition Temperature: 
Solubility in water: 
Specific Gravity/Density: 
Molecular Formula: C5H5NO 
Molecular Weight: 95.10 

Section 10 - STABILITY AND REACTIVITY
Chemical Stability: 
Stable under normal temperatures and pressures. 
Conditions to Avoid: 
Incompatible materials, strong oxidants. 
Incompatibilities with Other Materials: 
Oxidizing agents. 
Hazardous Decomposition Products: 
Irritating and toxic fumes and gases. 
Hazardous Polymerization: Not available. 

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#: 
CAS# 108-96-3 unlisted. 
LD50/LC50: 
Not available. 
Carcinogenicity: 
4-(1H)-Pyridone - Not listed by ACGIH, IARC, or NTP. 

Section 12 - ECOLOGICAL INFORMATION


Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations. 

Section 14 - TRANSPORT INFORMATION

IATA 
Not regulated as a hazardous material. 
IMO 
Not regulated as a hazardous material. 
RID/ADR 
Not regulated as a hazardous material. 

Section 15 - REGULATORY INFORMATION

European/International Regulations 
European Labeling in Accordance with EC Directives 
Hazard Symbols: Not available. 
Risk Phrases: 
Safety Phrases: 
S 24/25 Avoid contact with skin and eyes. 
S 28A After contact with skin, wash immediately with 
plenty of water. 
S 37 Wear suitable gloves. 
S 45 In case of accident or if you feel unwell, seek 
medical advice immediately (show the label where 
possible). 
WGK (Water Danger/Protection) 
CAS# 108-96-3: No information available. 
Canada 
CAS# 108-96-3 is listed on Canada‘s NDSL List. 
CAS# 108-96-3 is not listed on Canada‘s Ingredient Disclosure List. 
US FEDERAL 
TSCA 
CAS# 108-96-3 is listed on the TSCA inventory. 


SECTION 16 - ADDITIONAL INFORMATION
N/A 

安全信息

[ 危险品标志 ]: Xi: Irritant;
[ 危险类别码 ]: R36/37/38
[ 安全说明 ]: S26-S36
[ WGK Germany ]: 3
[ RTECS号 ]: UU7701450

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吡啶酮

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原文地址:http://www.cnblogs.com/juqiang/p/5691062.html

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