标签：
幽门螺旋菌感染者中，80%没有临床反应，10-20%感染者有胃溃疡，十二指肠溃疡，1-2%感染者有胃癌风险，1%有食道癌风险。
幽门螺旋菌感染者营养吸收差，缺铁，全身器官疾病诱因，可引起细胞凋亡，引发胃炎等等。
Martin J. Blaser认为幽门螺旋菌是肠胃正常细菌份子，可以帮助人体控制食欲，较少哮喘，食管反流，食管癌等等。
幽门螺旋菌是一种古老细菌，与人类共存数万年，推测来源于非洲和东亚。数万年共存让幽门螺旋菌进化为更好与人相处，共同存亡，也可杀死人类。
总之幽门螺旋菌有非常复杂机制，我们只是用当前发现概况事实的全部。评价幽门螺旋菌好坏值得进一步研究。
H. pylori colonizes the stomach and induces chronic gastritis, a long-lasting inflammation of the stomach. The bacterium persists in the stomach for decades in most people. Most individuals infected by H. pylori will never experience clinical symptoms despite having chronic gastritis. About 10–20% of those colonized by H. pylori will ultimately develop gastric and duodenal ulcers.[11] H. pylori infection is also associated with a 1–2% lifetime risk of stomach cancer and a less than 1% risk of gastric MALT lymphoma.[11]
In the absence of treatment, H. pylori infection—once established in its gastric niche—is widely believed to persist for life.[6] In the elderly, however, infection likely can disappear as the stomach‘s mucosa becomes increasingly atrophic and inhospitable to colonization. The proportion of acute infections that persist is not known, but several studies that followed the natural history in populations have reported apparent spontaneous elimination.[70][71]
Mounting evidence suggests H. pylori has an important role in protection from some diseases. The incidence of acid reflux disease, Barrett‘s esophagus, and esophageal cancer have been rising dramatically at the same time as H. pylori‘s presence decreases.[72] In 1996, Martin J. Blaser advanced the hypothesis that H. pylori has a beneficial effect: by regulating the acidity of the stomach contents.[37][72] The hypothesis is not universally accepted as several randomized controlled trials failed to demonstrate worsening of acid reflux disease symptoms following eradication of H. pylori.[73][74] Nevertheless, Blaser has reasserted his view that H. pylori is a member of the normal flora of the stomach.[75] He postulates that the changes in gastric physiology caused by the loss of H. pylori account for the recent increase in incidence of several diseases, including type 2 diabetes, obesity, and asthma.[75][76] His group has recently shown that H. pylori colonization is associated with a lower incidence of childhood asthma.[77]
标签：
原文地址：http://www.cnblogs.com/biopy/p/4295713.html
